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Cystic Fibrosis Trust

Trials Tracker

Welcome to the Trials Tracker, bringing together all the cystic fibrosis (CF) trials currently recruiting in the UK so that you can find clinical trials you can take part in both in your region and further afield. The Trials Tracker is a new resource that we’ll be developing over time based on your feedback. If you’ve used the Trials Tracker and want to share your opinion, please complete our online poll or get in touch at clinicaltrials@cysticfibrosis.org.uk.

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Clinical trials

1-5 of 40 results for all trials

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Trial status

Inclusion age

FEV1

Trial type

Location

Mutation

Therapeutic category

HOPE-1

Evaluation of potential mucus clearing treatment for all patients with CF regardless of mutation

Phase II
  • Age

    18+

  • Therapeutic category

    Mucociliary Clearance

VX17-659-102

This study will evaluate the efficacy of VX-659 in triple combination with Tezacaftor and Ivacaftor in subjects with cystic fibrosis who are heterozygous for F508del and a minimal function mutation

  • Mutation

    One copy of F508del

  • Length of participation

    24 weeks

  • Therapeutic category

    Restore CFTR Function

A Study Looking at the Safety, Tolerability and Efficacy of the Combination of the Study Drugs GLPG2451 and GLPG2222 With or Without GLPG2737 in Patients With Cystic Fibrosis (FALCON)

This is a Phase Ib, multi-center, open-label, non randomized multiple cohorts study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of a combination treatment of GLPG2451 and GLPG2222, with and without GLPG2737, in adult subjects with Cystic Fibrosis.

Phase I
  • Age

    18+

  • Trial status

    Open to recruitment

  • Therapeutic category

    Restore CFTR Function

LIMBuS

Lung clearance index (LCI) measure by multi-breath washout (MBW) has been shown to be sensitive and a non-invasive way of picking up early airways disease in infants with cystic fibrosis (CF). Abnormal measurements at a young age have been shown to track into later life and could identify children who need more aggressive treatment early. Currently there is a lack of data and suitable ways of performing this in multiple, non-specialised centres. This is a multi-centre longitudinal observational study of this measurement in children under 3 years of age with CF with a healthy control group and a disease comparison group of babies who are born early. A novel method for MBW in infants will be used which has been developed and assessed in a pilot study prior to this. We aim to show that LCI can be reliably measured across multiple centres using this method with high rates of success and that the measurements are repeatable in the short term (2-3 months). Any changes in this measurement in the CF infants and children will also be shown over 12-18 months. All parents will be consented prior to taking part and the children will be sedated as per local protocol at lower doses than usual. The CF children will be seen after recruitment, 2-3 months and 12-18 months later. The babies will be seen prior to discharge from the neonatal unit and 12 months later. The healthy children will be seen opportunistically when sedated for MRI scans in radiology and measurements taken whilst still asleep.

  • Trial status

    Open to recruitment

  • Therapeutic category

    Other

VX17-445-102

This study will evaluate the efficacy of VX-445 in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are heterozygous for F508del and a minimal function mutation

Phase 3
  • Mutation

    One copy of F508del

  • Trial status

    Project in Setup

  • Therapeutic category

    Restore CFTR Function

1-5 of 40 results for all trials